An exploratory cost-effectiveness analysis of a novel tissue valve compared with mechanical valves for surgical aortic valve replacement in subgroups of people aged 55–64 and 65+ with aortic stenosis in the UK.

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Authors
Nikolaidis, Nicolas
Issue Date
2023-08-28
Type
Article
Peer-Reviewed Publication
Keywords
Aortic stenosis
Aortic valve replacement
Bioprosthetic valve
Cost-effectiveness
Health economics
National Health Service
Peer-reviewed article
Surgical aortic valve replacement
United Kingdom
Journal
Expert Review of Pharmacoeconomics & Outcomes Research
Volume
Issue
Research Projects
Organizational Units
Journal Issue
Alternative Title
Abstract
Objective Exploratory analysis to conceptualize and evaluate the potential cost-effectiveness and economic drivers of using a novel tissue valve compared with mechanical heart valves for surgical aortic valve replacement (SAVR) in people aged 55–64 and 65+ with aortic stenosis (AS) from a National Health Service (NHS) UK perspective. Methods A decision-analytic model was developed using a partitioned survival model. Parameter inputs were obtained from published literature. Deterministic and probabilistic sensitivity analyses (DSA and PSA) were conducted to explore the uncertainty around the parameters. Results The novel tissue valve was potentially associated with higher quality-adjusted life years (QALYs) of 0.01 per person. Potential cost savings were greatest for those aged 55–64 (£408) versus those aged 65+(£53). DSA indicated the results to be most dependent on relative differences in general mortality, procedure costs, and reoperation rates. PSA estimated around 75% of the iterations to be cost-effective at £20,000 per QALY for those aged 55–64, and 57% for those aged 65+. Conclusions The exploratory analysis suggests that the novel tissue valve could be a cost-effective intervention for people over the age of 55 with AS who are suitable for SAVR in the UK.
Description
Received 9th March 2023. Accepted 14th August 2023. Published online 28th august 2023.
Citation
Malcolm R, Buckley C, Shore J, Stainthorpe A, Marti B, White A, Deckert J, Vernia M, Carapinha JL, López-Marco A, Nikolaidis N, Wendler O. An exploratory cost-effectiveness analysis of a novel tissue valve compared with mechanical valves for surgical aortic valve replacement in subgroups of people aged 55-64 and 65+ with aortic stenosis in the UK. Expert Rev Pharmacoecon Outcomes Res. 2023 Aug 28:1-13. doi: 10.1080/14737167.2023.2249611. Epub ahead of print. PMID: 37638585.
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