Rhegmatogenous retinal detachment following intravitreal ocriplasmin.

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Authors
Price, Nick
Issue Date
2016-12-01
Journal
Type
Article
Peer-Reviewed Publication
Keywords
Aged
Female
Fibrinolysin
Follow-up studies
Intravitreal injections
Macular hole
Male
Microplasmin
Middle aged
Multicentre study
Observational study
Ocriplasmin
Optical coherence tomography
Peer reviewed article
Peptide fragments
Pharmacological vitreolysis
Prognosis
Retina
Retinal detachment
Retinal perforation
Retinal tears
Retrospective study
Visual acuity
Vitreous detachment
Vitroemacular traction
Journal Title
Graefe's Archive for Clinical and Experimental Ophthalmology
Volume
254
Issue
12
Begin page
2333
End page
2338
Abstract
Purpose: To describe the characteristics and outcomes of patients presenting with rhegmatogenous retinal detachment (RRD) after ocriplasmin (OCP) injection. Methods: Retrospective, multi-centre, observational case series with case note review. Results: Eight patients with symptomatic vitreomacular traction (six with concomitant macular hole) were diagnosed with RRD after a median of 16 days (range 3-131 days) post-OCP injection. Presentation was within 3 weeks of the OCP injection in six of the cases. Five patients presented with symptoms post-OCP, and three were diagnosed asymptomatically on planned visits. Seven cases were phakic, one had high myopia (>8 dioptres), and two cases had lattice degeneration. Following RRD surgery, hole closure was achieved in 5/6 MH cases. The final median BCVA at 7 months was 20/80 (range 20/40-20/1200) similar to the baseline BCVA 20/80, with four patients gaining ≥1 line of vision compared to baseline but three losing ≥3 lines. Conclusions: RRD is a non-negligible risk associated with intravitreal OCP, and it should be used with caution in eyes with high myopia and peripheral retinal pathology predisposing to RRD. Detailed peripheral retinal examination is recommended pre- and postoperatively at all visits. Patients should be advised to seek attention if symptoms recur after initial presentation.
Citation
Madi HA, Haynes RJ, Depla D, de la Cour MD, Lesnik-Oberstein S, Muqit MM, Patton N, Price N, Steel DH. Rhegmatogenous retinal detachment following intravitreal ocriplasmin. Graefes Arch Clin Exp Ophthalmol. 2016 Dec;254(12):2333-2338. doi: 10.1007/s00417-016-3398-7. Epub 2016 Jun 8. PMID: 27278373; PMCID: PMC5116307.