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Treatment adaptations and outcomes of patients experiencing inflammatory bowel disease flares during the early COVID-19 pandemic: the PREPARE-IBD multicentre cohort study.
(Alimentary Pharmacology and Therapeutics (AP&T)., Wiley Online., 2022-10-05)Background The COVID-19 pandemic offered a unique opportunity to understand inflammatory bowel disease (IBD) management during unexpected disruption. This could help to guide practice overall. Aims To compare prescribing ... -
Effect of automated feedback laboratory comments promoting good phlebotomy practice on the frequency of ethylenediaminetetraacetic acid (EDTA) contamination of serum samples.
(Annals of Clinical Biochemistry, Sage Journals., 2023-01-01)Background Ethylenediaminetetraacetic acid (EDTA) contamination of serum samples is common but under-recognized unless EDTA is measured. Incorrect order of draw with closed phlebotomy (vacutainer) does not cause EDTA ... -
Diagnostic performance of serum calprotectin in discriminating active from inactive ulcerative colitis in an outpatient setting.
(Annals of Clinical Biochemistry, Sage Journals, 2022-08-03)There are limited and conflicting data on the value of serum calprotectin (sCp) in discriminating active from inactive disease activity in ulcerative colitis (UC). Faecal calprotectin (fCp), sCp, serum C-reactive protein ... -
Neonatal BCG: a time for change.
(Archives of Disease in Childhood - Education and Practice, BMJ Journals, 2022-08-25)The BCG vaccination programme in the UK is risk based and has usually been given to eligible babies soon after birth. On advice from the Joint Committee on Vaccination and Immunisation, NHS England and Improvement recently ... -
Maximising the use of scarce qPCR master mixes.
(International Journal of Molecular Sciences, MDPI, 2022-07-30)The COVID-19 pandemic resulted in a universal, immediate, and vast demand for comprehensive molecular diagnostic testing, especially real-time quantitative (qPCR)-based methods. This rapidly triggered a global shortage of ... -
Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study.
(European Journal of Obstetrics and Gynecology and Reproductive Biology, Elsevier, 2022-09-01)Objective To assess perinatal outcomes for pregnancies affected by suspected or confirmed SARS-CoV-2 infection. Methods Prospective, web-based registry. Pregnant women were invited to participate if they had suspected ... -
COVID-19 seroprevalence after the first UK wave of the pandemic and its association with the physical and mental wellbeing of secondary care healthcare workers
(Brain, Behavior, & Immunity - Health, Elsevier, 2022-10-01)Objectives: To determine the seroprevalence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibody status amongst healthcare workers (HCWs) working through the first wave of the Coronavirus (COVID-19) ... -
The role of cardiac magnetic resonance imaging in the assessment of heart failure with preserved ejection fraction.
(Frontiers in Cardiovascular Medicine, Frontiers, 2022-07-18)Heart failure (HF) is a major cause of morbidity and mortality worldwide. Current classifications of HF categorize patients with a left ventricular ejection fraction of 50% or greater as HF with preserved ejection fraction ... -
Maternal iron deficiency anaemia in pregnancy: lessons from a national audit.
(British Journal of Haematology, Wiley Online, 2022-08-03)We describe the management and the prevalence of iron deficiency anaemia (IDA) during pregnancy by comparison to standards. A cross-sectional national cohort study of women who had given birth six weeks prior to data ... -
AHP student clinical supervision: whose role is it anyway?
(IHSCM, 2022-08-15)It is clear clinical staff face challenges in meeting placement demands. However, all registered staff have benefited from clinical placements in their career journey. It will be to our detriment if we do not rise to the ... -
Don’t ignore your pelvic floor!
(Institute of Health and Social Care Management, 2022-08-11)Many people feel uncomfortable talking about pelvic health and find that it is a difficult conversation to bring up. Pelvic floor dysfunction affects both men and women and can have a significant impact on quality of life, ... -
Effectiveness of somatosensory stimulation for the lower limb and foot to improve balance and gait after stroke: a systematic review.
(Brain Sciences, MDPI Journals, 2022-08-19)This systematic review’s purpose was to evaluate the effectiveness of lower-limb and foot somatosensory stimulation to improve balance and gait post-stroke. PRISMA reporting guidelines were followed. Included studies: ... -
A single faecal bile acid stool test demonstrates potential efficacy in replacing SeHCAT testing for bile acid diarrhoea in selected patients.
(Scientific Reports, Springer Nature, 2022-05-18)This study examines the validity of measuring faecal bile acids (FBA) in a single stool sample as a diagnostic tool for bile acid diarrhoea (BAD) by direct comparison to the 75selenium-homotaurocholic acid (SeHCAT) scan. ... -
Autoimmune hypoglycaemia: a narrative review from the laboratory perspective.
(Journal of Laboratory and Precision Medicine, AME Publishing Company., 2021-07-30)Whilst hypoglycaemia is common, autoimmune causes are relatively rare. Autoimmune causes of hypoglycaemia includes both insulin autoimmune syndrome (IAS), and type B insulin resistance syndrome (TBIR). IAS typically presents ... -
Variability in the pre-analytical stages influences microbiome laboratory analyses.
(MDPI journal, MDPI Journals, 2022-06-15)introduction: There are numerous confounding variables in the pre-analytical steps in the analysis of gut microbial composition that affect data consistency and reproducibility. This study compared two DNA extraction methods ... -
Sensory stimulation of the foot and ankle early post-stroke: a pilot and feasibility study.
(Frontiers in Neurology, Frontiers Media, 2021-07-05)Background: Somatosensory stimulation of the lower extremity could improve motor recovery and walking post-stroke. This pilot study investigated the feasibility of a subsequent randomized controlled trial (RCT) to determine ... -
The mutual benefits of patient and public involvement in research: an example from a feasibility study (MoTaStim-Foot).
(Research Involvement and Engagement, Springer Nature, 2021-12-04)Background: Patient and public involvement (PPI) in research has increased steadily over the last two decades and is now both expected and appropriately resourced by many funding bodies, including the National Institute ... -
Ambulatory care management of 69 patients with acute severe ulcerative colitis in comparison to 695 inpatients: insights from a multicentre UK cohort study.
(BMJ Open Gastroenterology, BMJ Journals, 2022-01-31)Introduction: Acute severe ulcerative colitis (ASUC) traditionally requires inpatient hospital management for intravenous therapies and/or colectomy. Ambulatory ASUC care has not yet been evaluated in large cohorts. Aims: ... -
Iron deficiency anaemia: pathophysiology, assessment, practical management.
(BMJ Open Gastroenterology, BMJ Publishing Group, 2022-01-01)The WHO has recognised iron deficiency anaemia (IDA) as the most common nutritional deficiency in the world, with 30% of the population being affected with this condition. Although the most common causes of IDA are ...
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