• The issue with osmotic shock hemolysate preparation procedure. 

  Kalaria, Tejas (Annals of Laboratory Medicine, Korean Society for Laboratory Medicine., 2023-08-01)

  No abstract available.

• Managing ethylenediaminetetraacetic acid (EDTA) interference in EDTA contaminated samples - selectivity in reporting analytes. 

  Kalaria, Tejas; Ford, Clare; Gama, Rousseau (Annals of Clinical Biochemistry, Sage., 2023-03-01)

  Background: The widely accepted practice of not reporting any results from ethylenediaminetetraacetic acid (EDTA) contaminated samples necessitates repeat phlebotomy and could delay clinical management decisions. EDTA, ...

• Removal of an embedded "covered" biliary stent by the "stent-in-stent" technique. 

  Menon, Shyam (World Journal of Gastroenterology, Baishideng Publishing Group., 2013-09-28)

  A 46-year-old man was admitted with obstructive jaundice and cross-sectional imaging with computed tomography suggested distal biliary obstruction. A distal common bile duct stricture was found at endoscopic retrograde ...

• Widespread psammoma body formation arising in the background of a uterine serous carcinoma. 

  Salmons, Nabeel Andrew (International Journal of Surgical Pathology, Sage Journals., 2014-02-01)

  This report highlights a very rare phenomenon of widespread psammomatous calcification without accompanying epithelium, present in the background of a uterine serous carcinoma. Psammomatous calcification is associated with ...

• Thyroid autoantibodies. 

  Dwivedi, Shivangi Nikhil; Kalaria, Tejas; Buch, Harit (Journal of Clinical Pathology, BMJ Publishing Group, 2023-01-01)

  Thyroid-stimulating hormone (TSH) receptor antibody (TSH-R-Ab or TRAb) testing plays a pivotal role in arriving at the aetiological diagnosis in patients with thyrotoxicosis. A positive test establishes the diagnosis of ...

• The diagnosis of normocalcaemic hyperparathyroidism is strikingly dissimilar using different commercial laboratory assays. 

  Kalaria, Tejas; Fenn, Jonathan; Ford, Clare; Gama, Rousseau (Hormone and Metabolic Research, Thieme Verlag KG, 2022-07-01)

  We assessed the impact of intact parathyroid hormone (iPTH) and adjusted calcium analyses on Abbott, Roche and Siemens analytical platforms in the diagnosis of normocalcaemic primary hyperparathyroidism (NCPHPT). These ...

• Effect of automated feedback laboratory comments promoting good phlebotomy practice on the frequency of ethylenediaminetetraacetic acid (EDTA) contamination of serum samples. 

  Kalaria, Tejas; Ford, Clare; Gama, Rousseau (Annals of Clinical Biochemistry, Sage Journals., 2023-01-01)

  Background Ethylenediaminetetraacetic acid (EDTA) contamination of serum samples is common but under-recognized unless EDTA is measured. Incorrect order of draw with closed phlebotomy (vacutainer) does not cause EDTA ...

• Diagnostic performance of serum calprotectin in discriminating active from inactive ulcerative colitis in an outpatient setting. 

  Udegbune, Michael; Sharrod-Cole, Hayley; Townsend, Sarah; Allen, Benn; Brookes, Matthew James; Ford, Clare; Gama, Rousseau (Annals of Clinical Biochemistry, Sage Journals, 2022-08-03)

  There are limited and conflicting data on the value of serum calprotectin (sCp) in discriminating active from inactive disease activity in ulcerative colitis (UC). Faecal calprotectin (fCp), sCp, serum C-reactive protein ...

• Multicenter evaluation of the idylla genefusion in non-small-cell lung cancer. 

  Cashmore, Matthew (The Journal of Molecular Diagnostics, Elsevier., 2022-09-01)

  argeted therapy in lung cancer requires the assessment of multiple oncogenic driver alterations, including fusion genes. This retrospective study evaluated the Idylla GeneFusion prototype, an automated and ease-of-use (<2 ...

• A single faecal bile acid stool test demonstrates potential efficacy in replacing SeHCAT testing for bile acid diarrhoea in selected patients. 

  Kumar, Aditi; Jain, Manushri; Ford, Clare; Gama, Rousseau; Steed, Helen; Brookes, Matthew James; Hughes, Lauren Elizabeth (Scientific Reports, Springer Nature, 2022-05-18)

  This study examines the validity of measuring faecal bile acids (FBA) in a single stool sample as a diagnostic tool for bile acid diarrhoea (BAD) by direct comparison to the 75selenium-homotaurocholic acid (SeHCAT) scan. ...

• Autoimmune hypoglycaemia: a narrative review from the laboratory perspective. 

  Hughes, Lauren Elizabeth; Fenn, Jonathan Samuel; Ford, Clare; Gama, Rousseau (Journal of Laboratory and Precision Medicine, AME Publishing Company., 2021-07-30)

  Whilst hypoglycaemia is common, autoimmune causes are relatively rare. Autoimmune causes of hypoglycaemia includes both insulin autoimmune syndrome (IAS), and type B insulin resistance syndrome (TBIR). IAS typically presents ...

• Gluten induces subtle histological changes in duodenal mucosa of patients with non-coeliac gluten sensitivity: a multicentre study. 

  Lu, Laura (Nutrients, MDPI journal, 2022-06-15)

  Background: Histological changes induced by gluten in the duodenal mucosa of patients with non-coeliac gluten sensitivity (NCGS) are poorly defined. Objectives: To evaluate the structural and inflammatory features of NCGS ...

• Hydatidiform mole quality improvement project (QIP): experience of a newly established NHS pathology hub. 

  Kelly, Rebecca; Abu-Sinn, Duaa (The Royal Wolverhampton NHS Trust., 2022-06-09)

  Hydatidiform molar pregnancies have more favourable outcomes when there is effective and timely communication between local hospitals and Centres for Trophoblastic Disease (CTD). Our QIP reviews ways to make our referral ...

• Mixed endometrioid adenocarcinoma and Mullerian adenosarcoma of the uterus – a case report and review of the literature. 

  Osman, Rania; Abu-Sinn, Duaa (The Royal Wolverhampton NHS Trust., 2022-06-09)

  An interesting case of mixed endometrioid adenocarcinoma and Mullerian adenosarcoma of the uterus.

• Mixed carcinoma of the uterine corpus, the “real deal” versus the “imposter”. 

  Osman, Rania; Benes, Ksenija; Abu-Sinn, Duaa (The Royal Wolverhampton NHS Trust., 2022-06-09)

  Two very interesting cases of ‘mixed’ carcinoma of the uterine corpus. Can you guess which is the imposter?

• Impact of COVID-19 pandemic on workload in gynaecological pathology – experience of an NHS pathology hub. 

  Roberts, Sarah; Abu-Sinn, Duaa (The Royal Wolverhampton NHS Trust., 2022-06-09)

  A review of the impact of Covid-19 on gynaecological pathology workload – comparing pre-pandemic, lockdowns, and Covid-recovery period.

• The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM) 

  Livingston, Mark (Endocrinology Diabetes & Metabolism, Wiley Online Library, 2022-03-01)

  Background Finger prick blood glucose (BG) monitoring remains a mainstay of management in people with type 2 diabetes (T2DM) who take sulphonylurea (SU) drugs or insulin. We recently examined patient experience of BG ...

• What is the value of the 60-minute cortisol measurement in the short synacthen test (SST)? evidence for the defence. 

  Livingston, Mark (International Journal of Clinical Practice, Wiley Online Library, 2022-03-01)

  The 60-minute cortisol retains utility as part of the SST. Reliance on a 60-minute cortisol level can identify all normal and abnormal responses, while relying on 30-minute cortisol level alone ...

• Mortality rate associated with diabetes: outcomes from a general practice level analysis in England using the Royal College of General Practitioners (RCGP) database indicate stability over a 15 year period. 

  Livingston, Mark (Diabetes Therapy, Springer Link, 2022-03-01)

  Introduction Total population mortality rates have been falling and life expectancy increasing for more than 30 years. Diabetes remains a significant risk factor for premature death. Here we used the Oxford Royal College ...

• Utility of plasma NGAL for the diagnosis of AKI following cardiac surgery requiring cardiopulmonary bypass: a systematic review and meta-analysis. 

  Sharrod-Cole, Hayley; Fenn, Jonathan; Gama, Rousseau; Ford, Clare; Giri, Ramesh; Luckraz, Heyman (Scientific Reports, Springer Nature, 2022-04-19)

  The objective of this study was to assess the diagnostic value of plasma neutrophil gelatinase-associated lipocalin (pNGAL) for the early diagnosis of acute kidney injury (AKI) in adult patients following cardiac surgery ...

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