• People with type 2 diabetes mellitus (T2DM) self-reported views on their own condition management reveal a high level of insight into the challenges faced. 

  Livingston, Mark (Journal of Diabetes Science and Technology, Sage Journals, 2021-05-17)

  No abstract available.

• Differences in the on- and off-tumor microbiota between right- and left-sided colorectal cancer. 

  Steed, Helen; Kumar, Aditi; Brookes, Matthew James (Microorganisms, MDPI, 2021-05-20)

  This study aims to determine differences in the on- and off-tumor microbiota between patients with right- and left-sided colorectal cancer. Microbiome profiling of tumor and tumor-adjacent biopsies from patients with ...

• Biochemical assessment of adequate levothyroxine replacement in primary hypothyroidism differs with different TSH assays: potential clinical implications. 

  Kalaria, Tejas; Sanders, Anna; Ford, Clare; Fenn, Jonathan Samuel; Ashby, Helen L; Mohammed, Pervaz; Gama, Rousseau (Journal of Clinical Pathology, BMJ Publishing Group, 2021-05-14)

  Aim: Thyroid stimulating hormone (TSH) assays provided by Abbott Laboratories and Roche Diagnostics are used by approximately 75% of laboratories in the UK. We assessed the potential impact of Abbott and Roche TSH assay ...

• The hidden endoscopic burden of sleeve gastrectomy and its comparison with Roux-en-Y gastric bypass. 

  Steed, Helen (Annals of Gastroenterology, Hellenic Society of Gastroenterology, 2016-01-01)

  Background Th is study aimed to assess the endoscopic burden of bariatric surgical procedures at our trust. Th is is an enhanced parallel study to “Th e Hidden Endoscopic burden of Roux-en-Y Gastric Bypass” published ...

• Efficacy of reduced-intensity chemotherapy with oxaliplatin and capecitabine on quality of life and cancer control among older and frail patients with advanced gastroesophageal cancer: the GO2 phase 3 randomized clinical trial. 

  Mano, Joseph (JAMA Oncology, American Medical Association, 2021-05-13)

  Importance: Older and/or frail patients are underrepresented in landmark cancer trials. Tailored research is needed to address this evidence gap. Objective: The GO2 randomized clinical trial sought to optimize chemotherapy ...

• Longitudinal complications associated with PEG: Rate and severity of 30-day and 1-year complications experienced by patients after primary PEG insertion. 

  Barrett, Diane; Li, Vincent; Merrick, Susan; Helen, Steed (Clinical Nutrition ESPEN, Elsevier, 2021-06-01)

  Background and aims: Percutaneous Endoscopic Gastrostomy (PEG) feeding is utilised in patients with exceptionally poor oral intake but is associated with both short and long-term complications. This study reviews longitudinal ...

• Absence of monitoring in withdrawal of clinically-assisted nutrition and hydration (CANH) and other treatments: a cause for concern? 

  Gray, Alice (Clinical Medicine Journal, Royal College of Physicians, 2021-05-17)

  Since 2018, there has been no requirement to bring decisions about the withdrawal of clinically-assisted nutrition and hydration (CANH) in patients with persistent disorders of consciousness before the courts, providing ...

• Impact of hyperthyroidism and its treatment on the outcome of mental health, occupational functioning and quality of life - a prospective study. 

  Chopra, Roopa; Kalaria, Tejas; Gherman-Ciolac, Carolina; Raghavan, Rajeev; Viswanath, Ananth; Buch, Harit (Journal of the Endocrine Society, Oxford Acadamic, 2020-04-01)

  Hyperthyroidism is known to be associated with psychiatric symptoms such as anxiety and depression, impartment of functioning and poor quality of life (QOL). It was intended to study the outcome of anxiety, depression, ...

• The use of genomic assays reduces rates of chemotherapy: a single-institution experience. 

  Vatish, Jamie; Wilkinson, Ben; Al-Ishaq, Zaid; Pujji, Ojas; Isgar, Brian; Vidya, Raghavan; Matey, Pilar; Sircar, Tapan; Mylvaganam, Sylvaganam (Irish Journal of Medical Science, Springer Nature, 2021-05-15)

  Introduction: The National Institute for Clinical Excellence recommends the use of tumour profiling tests to guide adjuvant chemotherapy in breast cancer. The Oncotype DX™ score (Genomic Health) has superseded more traditional ...

• How should complete lung collapse secondary to primary spontaneous pneumothorax be managed? 

  Afridi, Muhammad Amin (Clinical Medicine, Journal of the Royal College of Physicians of London, 2019-03-14)

  Management of primary spontaneous pneumothorax (PSP) depends on the symptoms and size of lung collapse. The British Thoracic Society recommends needle aspiration (NA) for all PSP requiring intervention, followed by intercostal ...

• Self-insertion of urethral foreign body: a simple endoscopic technique for removal of a metal forceps from male urethra. 

  Abouelazayem, Mohamed (Urology Case Reports, Elsevier, 2019-02-19)

  22 year old male presented with self insertion of a foreign body in his urethra 4 years ago. The metal forceps was successfully extracted endoscopically with the aid of the external pressure technique. This is the second ...

• Sensor and software use for the glycaemic management of insulin-treated type 1 and type 2 diabetes patients. 

  Singh, Baldev. M. (Diabetes & Vascular Disease Research, SAGE Publications, 2016-05-01)

  Lowering glucose levels, while avoiding hypoglycaemia, can be challenging in insulin-treated patients with diabetes. We evaluated the role of ambulatory glucose profile in optimising glycaemic control in this population. ...

• A 5-year assessment of the epidemiology and natural history of possible diabetes in remission. 

  Gillani, Syed M R; Raghavan, Rajeev; Singh, Baldev (Primary Care Diabetes, Elsevier, 2021-05-06)

  Introduction: Type 2 diabetes is considered a chronic and progressive disease. The term diabetes in remission has no consensus definition and the question whether diabetes "remission" or "cure" can achieve any long-term ...

• X chromosome contribution to the genetic architecture of primary biliary cholangitis 

  Green, Marie; Sirdefield, Dawn; Amor, Kelly; Brookes, Matthew; Mathew, Ray (Gastroenterology, Elsevier, 2021-03-04)

  Background & aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to ...

• The top 10 research priorities in diabetes and pregnancy according to women, support networks and healthcare professionals. 

  Lowe-Zinola, Jack; Magdi, Fida; Churchill, David (Diabetic Medicine, Wiley Online, 2021-05-05)

  Aims: To undertake a Priority Setting Partnership (PSP) to establish priorities for future research in diabetes and pregnancy, according to women with experience of pregnancy, and planning pregnancy, with any type of ...

• Development of a 223radium dichloride (Xofigo) patient pathway for metastatic castrate-resistant prostate cancer (mCRPC) that prresent to the The Royal Wolverhampton NHS Trust following an alert by the Medicines and Healthcare Products Regulatory Agency (6th August 2018). 

  Weekes, Jo; Sayers, Ian; Foley, Malcomb (The Royal Wolverhampton NHS Trust, 2018-10-10)

  Nobody knows the exact number in the UK, but approximately 90% of the prostate cancer deaths per year in this country are from cancer that has metastasized to bone. There are various possible sequences of therapy available ...

• A follow up dose-rate measurement strategy for patients post 131Iodine ablation therapy: can we improve the post treatment restrictions applied to the patient on discharge? 

  Weekes, Jo; Foley, Malcolm; Tripathi, Dev (The Royal Wolverhampton NHS Trust., 2018-10-10)

  131Iodine Ablation Therapy is used in the treatment of some thyroid cancers, specifically papillary and follicular thyroid cancer. The patients are referred post thyroidectomy, for post-operative radioactive iodine ablation ...

• Iodine restricting diet prior to radioiodine therapy (RAI) for hyperthyroidism - does it help? 

  Weekes, Jo; Buch, Harit; Nabi, Syed Assad (The Royal Wolverhampton NHS Trust., 2018-09)

  Background: There has been conflicting evidence on the use of strict dietary iodine restriction prior to Radioiodine (RAI) administration for the management of hyperthyroidism and varying level of restrictions have been ...

• Bio distribution mapping of 223radium dichloride during the course of treatments 2 to 6: a patient case study. 

  Sayers, Ian; Weekes, Jo; Foley, Malcolm (The Royal Wolverhampton NHS Trust., 2018-10-10)

  Prostate cancer is diagnosed in over 47,000 men per year in the UK and caused 11,631 deaths in 2016 (1). 90% of men with the disease have bone metastases (2) , and in 80% these cause debilitating pain or other symptoms. ...

• RePHILL: protocol for a randomised controlled trial of pre-hospital blood product resuscitation for trauma. 

  Herbert, Mike (Transfusion Medicine, Wiley, 2018-11)

  Objectives: To describe the 'Resuscitation with Pre-HospItaL bLood products' trial (RePHILL) - a multi-centre randomised controlled trial of pre-hospital blood product (PHBP) administration vs standard care for traumatic ...

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