Gastroenterology and Hepatology Services
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Recent Submissions
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Everolimus for previously treated advanced gastric cancer: results of the randomized, double-blind, phase III GRANITE-1 study.
(Journal of Clinical Oncology, American Social of Clinical Oncology, 2013-11-01)Purpose The oral mammalian target of rapamycin inhibitor everolimus demonstrated promising efficacy in a phase II study of pretreated advanced gastric cancer. This international, double-blind, phase III study compared ... -
The role of near-patient coeliac serology testing in the follow-up of patients with coeliac disease.
(BMJ Journals, BMJ Journals, 2014-01-01)Objective This pilot study was undertaken to assess the validity and effectiveness of near-patient coeliac immunological testing, compared to standard laboratory immunological techniques, used in the context of dietician-led ... -
Decompensated cirrhosis: targeted training of acute medical teams to improve quality of care in first 24 hours.
(British Journal of Nursing, MA Healthcare, 2022-11-24)Background: A quality improvement project in a secondary care centre was initiated to investigate and evaluate the impact of staff education and the use of the British Society of Gastroenterology/British Association for ... -
Metachronous colorectal cancer: a competing risks analysis with consideration for a stratified approach to surveillance colonoscopy.
(Journal of Surgical Oncology, Wiley Online, 2014-04-01)Background The incidence of metachronous cancer will become an important clinical consideration as the life expectancy of the population increases and as rates of curative resection improve. Objective To assess the ... -
ERCP in cholangitis.
(Gastrointestinal Endoscopy, Elsevier., 2014-02-01)Navaneethan et al1 present elegant data examining the variables associated with 30-day readmission in patients undergoing ERCP for cholangitis. However, the methodology used for their statistical analysis deserves critique ... -
Venous thromboembolism following discharge from hospital in patients admitted for inflammatory bowel diseases - authors reply.
(Journal of Crohns and Coltis, Oxford Academic, 2022-10-22)No abstract available. -
Treatment adaptations and outcomes of patients experiencing inflammatory bowel disease flares during the early COVID-19 pandemic: the PREPARE-IBD multicentre cohort study.
(Alimentary Pharmacology and Therapeutics (AP&T)., Wiley Online., 2022-10-05)Background The COVID-19 pandemic offered a unique opportunity to understand inflammatory bowel disease (IBD) management during unexpected disruption. This could help to guide practice overall. Aims To compare prescribing ... -
How commonly is upper gastrointestinal cancer missed at endoscopy? A meta-analysis.
(European International Open, Thieme Verlag KG, 2014-06-01)Background and study aims: Upper gastrointestinal (UGI) cancer in the Western world usually presents at an advanced stage, when opportunities for curative therapy are limited. The failure to detect subtle, early-stage UGI ... -
Expected value of artificial intelligence in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.
(Thieme., Thieme, 2022-10-21)This ESGE Position Statement defines the expected value of artificial intelligence (AI) for the diagnosis and management of gastrointestinal neoplasia within the framework of the performance measures already defined by ... -
Guidance on the management of diarrhoea during cancer chemotherapy.
(The Lancet Oncology., Elsevier., 2014-09-15)Diarrhoea induced by chemotherapy in cancer patients is common, causes notable morbidity and mortality, and is managed inconsistently. Previous management guidelines were based on poor evidence and neglect physiological ... -
Reducing the environmental footprint of gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastroenterology and Endoscopy Nurses and Associates (ESGENA) Position Statement.
(Endoscopy, Thieme Verlag KG, 2022-08-01)Climate change and the destruction of ecosystems by human activities are among the greatest challenges of the 21st century and require urgent action. Health care activities significantly contribute to the emission of ... -
Diagnostic performance of serum calprotectin in discriminating active from inactive ulcerative colitis in an outpatient setting.
(Annals of Clinical Biochemistry, Sage Journals, 2022-08-03)There are limited and conflicting data on the value of serum calprotectin (sCp) in discriminating active from inactive disease activity in ulcerative colitis (UC). Faecal calprotectin (fCp), sCp, serum C-reactive protein ... -
Disparities in risk stratification guidance for patients taking immunosuppressive drugs during the COVID-19 pandemic – points to ponder.
(Journal of the Royal College of Physicians of Edinburgh, Sage Journals, 2022-06-17)No abstract available. -
Is hormone replacement therapy in post-menopausal women associated with a reduced risk of oesophageal cancer?
(United European Gastroenterology Journal, Wiley Online, 2014-10-01)Purpose The rise in oesophageal adenocarcinoma incidence in women with age is delayed compared with men until the post-menopausal period. A matched cohort study was therefore undertaken of post-menopausal women on hormone ... -
Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial
(The Lancet, Elsevier., 2014-10-01)Background VEGFR-2 has a role in gastric cancer pathogenesis and progression. We assessed whether ramucirumab, a monoclonal antibody VEGFR-2 antagonist, in combination with paclitaxel would increase overall survival in ... -
Comparative cost-effectiveness of three post-radiofrequency ablation surveillance intervals for Barrett's esophagus.
(Endoscopy International Open, Thieme, 2022-08-15)Background and study aims Radiofrequency ablation (RFA) for dysplastic Barrett's esophagus (BE) has resulted in a paradigm shift in the management of BE. Despite widespread adoption of RFA, the optimal surveillance interval ... -
Venous thromboembolism following discharge from hospital in patients admitted for inflammatory bowel disease.
(Journal of Crohn's and Colitis (JCC), Oxford University Press, 2022-08-10)Background and Aims Patients admitted to hospital with Inflammatory bowel disease(IBD) are at increased risk of venous thromboembolism(VTE). This study aims to identify IBD patients at increased VTE risk on hospital ... -
A single faecal bile acid stool test demonstrates potential efficacy in replacing SeHCAT testing for bile acid diarrhoea in selected patients.
(Scientific Reports, Springer Nature, 2022-05-18)This study examines the validity of measuring faecal bile acids (FBA) in a single stool sample as a diagnostic tool for bile acid diarrhoea (BAD) by direct comparison to the 75selenium-homotaurocholic acid (SeHCAT) scan. ... -
Variability in the pre-analytical stages influences microbiome laboratory analyses.
(MDPI journal, MDPI Journals, 2022-06-15)introduction: There are numerous confounding variables in the pre-analytical steps in the analysis of gut microbial composition that affect data consistency and reproducibility. This study compared two DNA extraction methods ... -
Gluten induces subtle histological changes in duodenal mucosa of patients with non-coeliac gluten sensitivity: a multicentre study.
(Nutrients, MDPI journal, 2022-06-15)Background: Histological changes induced by gluten in the duodenal mucosa of patients with non-coeliac gluten sensitivity (NCGS) are poorly defined. Objectives: To evaluate the structural and inflammatory features of NCGS ...
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