Differences in the topographic profiles of retinal thickening in eyes with and without serous macular detachment associated with diabetic macular oedema.
AuthorShereef, Hannah; Comyn, Oliver; Sivaprasad, Sobha; Hykin, Philip; Cheung, Gemmy; Narendran, Nirodhini; Yang, Yit
TypeMulticentre Study; Peer-Reviewed Publication; Retrospective Study
KeywordOptical coherence tomography; Diabetic retinopathy; Imaging; Macula; Retina; Aged; Follow-up studies; Macular edema; Middle aged; Retinal detachment; Severity of illness index; Visual acuity
Journal TitleBritish Journal of Ophthalmology
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AbstractPurpose To investigate if cases of diabetic macular oedema (DMO) associated with serous macular detachment (SMD) have a different topographic profile of retinal thickening compared with DMO cases not associated with SMD. Methods Optical coherence tomography scans of 152 eyes from 152 patients with centre-involving DMO and central subfield thickness >350 µm were identified. Measurements were taken of the neural retina at the highest point of thickening within the central subfield (H) and lateral extent of retina thicker than 350 µm (W). Group means were compared between eyes with SMD and eyes without SMD. Results SMD was present in 55 eyes (36%). H was lower in eyes with SMD than in eyes without SMD (396 µm vs 550 µm, p<0.001) while W was higher in eyes with SMD compared with eyes without SMD (4.74 mm vs 4.18 mm, p=0.011). Conclusions There were distinct differences in topographical profiles of retinal thickening between eyes with SMD and eyes without SMD. These findings suggest a possible mechanical basis for the pathogenesis of SMD in DMO.
CitationShereef H, Comyn O, Sivaprasad S, Hykin P, Cheung G, Narendran N, Yang YC. Differences in the topographic profiles of retinal thickening in eyes with and without serous macular detachment associated with diabetic macular oedema. Br J Ophthalmol. 2014 Feb;98(2):182-7. doi: 10.1136/bjophthalmol-2013-303095. Epub 2013 Nov 13. PMID: 24227800.
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