Differences in the topographic profiles of retinal thickening in eyes with and without serous macular detachment associated with diabetic macular oedema.

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Authors
Cheung, Gemmy
Comyn, Oliver
Hykin, Philip
Narendran, Nirodhini
Shereef, Hannah
Sivaprasad, Sobha
Yang, Yit
Issue Date
2014-02-01
Journal
Type
Article
Peer-Reviewed Publication
Keywords
Adult
Aged
Diabetic retinopathy
Female
Follow-up studies
Imaging
Macula
Macular edema
Male
Middle aged
Multicentre study
Optical coherence tomography
Retina
Retinal detachment
Retrospective study
Severity of illness index
Visual acuity
Journal Title
British Journal of Ophthalmology
Volume
98
Issue
2
Begin page
End page
Abstract
Purpose To investigate if cases of diabetic macular oedema (DMO) associated with serous macular detachment (SMD) have a different topographic profile of retinal thickening compared with DMO cases not associated with SMD. Methods Optical coherence tomography scans of 152 eyes from 152 patients with centre-involving DMO and central subfield thickness >350 µm were identified. Measurements were taken of the neural retina at the highest point of thickening within the central subfield (H) and lateral extent of retina thicker than 350 µm (W). Group means were compared between eyes with SMD and eyes without SMD. Results SMD was present in 55 eyes (36%). H was lower in eyes with SMD than in eyes without SMD (396 µm vs 550 µm, p<0.001) while W was higher in eyes with SMD compared with eyes without SMD (4.74 mm vs 4.18 mm, p=0.011). Conclusions There were distinct differences in topographical profiles of retinal thickening between eyes with SMD and eyes without SMD. These findings suggest a possible mechanical basis for the pathogenesis of SMD in DMO.
Citation
Shereef H, Comyn O, Sivaprasad S, Hykin P, Cheung G, Narendran N, Yang YC. Differences in the topographic profiles of retinal thickening in eyes with and without serous macular detachment associated with diabetic macular oedema. Br J Ophthalmol. 2014 Feb;98(2):182-7. doi: 10.1136/bjophthalmol-2013-303095. Epub 2013 Nov 13. PMID: 24227800.