Venous thromboembolism following discharge from hospital in patients admitted for inflammatory bowel disease.
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Authors
Harvey, Philip
Issue Date
2023-01-27
Journal
Type
Multicentre Study
Observational Study
Peer-Reviewed Publication
Observational Study
Peer-Reviewed Publication
Keywords
Deep vein thrombosis
Pulmonary embolism
Inflammatory bowel disease
Pulmonary embolism
Inflammatory bowel disease
Journal Title
Journal of Crohn's and Colitis (JCC)
Volume
Issue
1
Begin page
103
End page
110
Abstract
Background and Aims
Patients admitted to hospital with Inflammatory bowel disease(IBD) are at increased risk of venous thromboembolism(VTE). This study aims to identify IBD patients at increased VTE risk on hospital discharge and develop a risk scoring system to recognise them.
Methods
Hospital episode statistics data were used to identify all patients admitted with IBD as an emergency or electively for surgery. All patients with VTE within 90 days of hospital discharge were identified. A multilevel logistic regression model was used to identify patient and admission level factors associated with VTE. A scoring system to identify higher risk patients for VTE was constructed.
Results
201,779 admissions in 101,966 patients were included. The rate of VTE within 90 days was 17.2 per 1000 patient years at risk and was highest in patients admitted as an emergency who underwent surgery(36.9).
VTE was associated with; female sex (odds ratio 0.65 (95%CI 0.53-0.80),p<0.001); increasing age (49-60 years(4.67(3.36-6.49),p<0.001)); increasing length of hospital stay (>10 days(3.80(2.80-5.15),p<0.001)); >2 hospital admissions in previous 3 months(2.23 (1.60-3.10),p<0.001); Ulcerative Colitis (1.48(1.21-1.82),p<0.001); and emergency admission including surgery(1.59(1.12-2.27),p=0.010) or emergency admission not including surgery(1.59(1.08-2.35), p=0.019) compared with elective surgery.
Citation
Harvey PR, Coupland B, Mytton J, De Silva S, Trudgill NJ. Venous thromboembolism following discharge from hospital in patients admitted for inflammatory bowel disease. J Crohns Colitis. 2022 Aug 10:jjac112. doi: 10.1093/ecco-jcc/jjac112. Epub ahead of print. PMID: 35948280.