What is the value of the 60-minute cortisol measurement in the short synacthen test (SST)? evidence for the defence.
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Authors
Livingston, Mark
Issue Date
2022-03-01
Journal
Type
Letter/Correspondence
Keywords
60-minute cortisol
Short synacthen test
Cortisol
Adrenocortical insufficiency
Hydrocortisone
Time factors
Humans
Short synacthen test
Cortisol
Adrenocortical insufficiency
Hydrocortisone
Time factors
Humans
Journal Title
International Journal of Clinical Practice
Volume
75
Issue
8
Begin page
e14417:1
End page
e14417:2
Abstract
The 60-minute cortisol retains utility as part of the SST. Reliance on a 60-minute cortisol level can identify all normal and abnormal responses, while relying on 30-minute cortisol level alone may falsely ascribe individuals to having adrenocortical insufficiency. It would surely be sensible to work towards a consensus in relation to inclusion of the 60-minute cortisol in all SST protocols, while taking into account the known variation in cortisol assay performance.
Citation
Stedman M, Rea R, Duff CJ, Livingston M, McLoughlin K, Wong L, Brown S, Grady K, Gadsby R, Gibson JM, Paisley A, Fryer AA, Heald AH. The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM). Endocrinol Diabetes Metab. 2022 Mar;5(2):e00302. doi: 10.1002/edm2.302. Epub 2021 Dec 17. PMID: 34921531; PMCID: PMC8917860.