Neurology Services

Permanent URI for this collection


Recent Submissions

Now showing 1 - 5 of 93
  • Item
    ATMOSPHERE: Artificial intelligence To Maximise and Optimise Seizure Prediction to EmpoweR people with Epilepsy.
    (ESNA, 2024-06-23) Tittensor, Phil
    The Atmosphere project exploits a machine learning algorithm, coupled with an intuitive smartphone app, to forecast an individual’s risk of experiencing a seizure. It is made up of three areas of development the machine learning algorithm, the wearable data recording device and the companion smartphone app. All development within the project is carried out with clinicians and people recruited from the Epilepsy Research Institute’s Shape Network and Epilepsy Action. Currently, focus is on participants from this and our PPI user group.
  • Item
    L-2-hydroxyglutaric aciduria: a report of clinical, radiological, and genetic characteristics of two siblings from Egypt.
    (Taylor & Francis online, 2024-04-01) Mahmoud, Ahmed Ali Mahmoud
    L-2-hydroxyglutaric aciduria (L-2-HGA) is a rare autosomal recessive disease characterized by elevated levels of hydroxyglutaric acid in the body fluids and brain with abnormal white matter. We present two siblings with psychomotor retardation and quadriparesis. Their brain imaging showed diffuse bilateral symmetrical involvement of the cerebral cortex, white matter, basal ganglia and cerebellum. The whole exome sequence studies revealed a homozygous likely pathogenic variant on chromosome 14q22.1 (NM_024884.2: c.178G > A; pGly60Arg) in the gene encoding for L-2-hydroxyglutarate dehydrogenase (L2HGDH) (OMIM #236792). Therefore, using the L2HGDH gene study is beneficial for L2HGA diagnosis.
  • Item
    Awareness of social care needs in people with epilepsy and intellectual disability.
    (Elsevier., 2023-08-01) Tittensor, Phil
    Background: Nearly a quarter of people with intellectual disability (ID) have epilepsy with large numbers experiencing drug-resistant epilepsy, and premature mortality. To mitigate epilepsy risks the environment and social care needs, particularly in professional care settings, need to be met. Purpose: To compare professional care groups as regards their subjective confidence and perceived responsibility when managing the need of people with ID and epilepsy. Method: A multi-agency expert panel developed a questionnaire with embedded case vignettes with quantitative and qualitative elements to understand training and confidence in the health and social determinants of people with ID and epilepsy. The cross-sectional survey was disseminated amongst health and social care professionals working with people with ID in the UK using an exponential non-discriminative snow-balling methodology. Group comparisons were undertaken using suitable statistical tests including Fisher's exact, Kruskal-Wallis, and Mann-Whitney. Bonferroni correction was applied to significant (p < 0.05) results. Content analysis was conducted and relevant categories and themes were identified. Results: Social and health professionals (n = 54) rated their confidence to manage the needs of people with ID and epilepsy equally. Health professionals showed better awareness (p < 0.001) of the findings/recommendations of the latest evidence on premature deaths and identifying and managing epilepsy-related risks, including the relevance of nocturnal monitoring. The content analysis highlighted the need for clearer roles, improved care pathways, better epilepsy-specific knowledge, increased resources, and better multi-disciplinary work. Conclusions: A gap exists between health and social care professionals in awareness of epilepsy needs for people with ID, requiring essential training and national pathways.
  • Item
    Diagnosis and management of subarachnoid haemorrhage.
    (Nature, 2024-02-29) Veenith , Tonny
    Aneurysmal subarachnoid haemorrhage (aSAH) presents a challenge to clinicians because of its multisystem effects. Advancements in computed tomography (CT), endovascular treatments, and neurocritical care have contributed to declining mortality rates. The critical care of aSAH prioritises cerebral perfusion, early aneurysm securement, and the prevention of secondary brain injury and systemic complications. Early interventions to mitigate cardiopulmonary complications, dyselectrolytemia and treatment of culprit aneurysm require a multidisciplinary approach. Standardised neurological assessments, transcranial doppler (TCD), and advanced imaging, along with hypertensive and invasive therapies, are vital in reducing delayed cerebral ischemia and poor outcomes. Health care disparities, particularly in the resource allocation for SAH treatment, affect outcomes significantly, with telemedicine and novel technologies proposed to address this health inequalities. This article underscores the necessity for comprehensive multidisciplinary care and the urgent need for large-scale studies to validate standardised treatment protocols for improved SAH outcomes.
  • Item
    The role and importance of nursing in epilepsy care: current and future prospects.
    (2023-06-13) Tittensor, Phil
    The role of nursing in epilepsy care is pivotal, requiring specialized education and support. The recent NICE guidelines emphasize the need for every person in the UK to have access to an epilepsy nurse, as basic nurse education lacks comprehensive coverage of epilepsy, necessitating post-registration education for career advancement and ensuring competent care.